Ciprodol is a clear colourless isotonic ophthalmic solution of Ciprofloxacin that is sterile until the bottle is opened. Each ml Ciprodol sterile ophthalmic solution contains Ciprofloxacin Hydrochloride USP which is equivalent to 3 mg Ciprofloxacin base and is preserved with benzalkonium chloride.

Ciprofloxacin is a fluoroquinolone antibacterial active against a broad-spectrum of gram-positive and gram-negative ocular pathogens. Ciprofloxacin shows its bactericidal action by interfering with the enzyme DNA-gyrase which is essential for the synthesis of bacterial DNA.

The minimum bactericidal concentration (MBC) generally does not exceed the minimum inhibitory concentration (MIC) by more than a factor of 2. Following ocular administration, the mean plasma concentration was usually less than 2.5 ng/ml and maximum reported plasma concentration was less than 5 ng/ml.

Ciprofloxacin is one of the most active fluoroquinolanes.lt is less resistant, does not cross - react with other antimicrobial agents such as beta-lactams, aminoglycosides. Therefore, organisms resistant to these drugs may be susceptible to Ciprofloxacin.

Ciprodol Eye Drops is indicated for the treatment of infections caused by susceptible strains of bacteria. It is indicated against the designated microorganisms in the conditions listed below:

Corneal ulcers : Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus (Viridans Group), Pseudomonas aeruginosa, Serratia marcescens.

Conjunctivitis: Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae.

Dosage and administration
Corneal ulcers : Instill two drops into the affected eye every 15 minutes for the first six hours and then two drops into the affected eye every 30 minutes for the remainder of the first day. On the second day, instill two drops into the affected eye hourly. On the third through the fourteenth day, place two drops in the affected eye every four hours. Treatment may be continued after 14 days if corneal re-epithelialization has not occurred.
Bacterial conjunctivitis : Instill one or two drops into the conjunctival sac (s) every two hours while awake for two days and one or two drops every four hours while awake for the next five days.

Contra-indications, warnings etc.

Hypersensitivity to Ciprofloxacin and other quinolones.

Not for injection into the eye.

As with other antibacterial preparations, prolonged use of ciprofloxacin may result in overgrowth of non-susceptible organisms, including fungi. If superinfection occurs, appropriate therapy should be initiated. Ciprofloxacin should be discontinued at the first appearance of a skin rash or any other sign of hypersensitivity reaction. During therapy, soft contact lenses should not be worn.

As there is no controlled study in pregnant women Ciprodol should be used during pregnancy only if the potential benefit justifies the potential risk of the foetus.

Excretion of ciprofloxacin into the human milk following topical ophthalmic administration has not been investigated but orally administered Ciprofloxacin is known to be excreted in the human breast milk. Therefore, caution should be exercised.

The safety and efficacy of Ciprodol in children under age of 12 years has not been established.

Local burning and ocular discomfort may occur as well as itching, foreign body sensation, lid margin crusting, crystals/scales, conjunctival hypermia and a bad taste following instillation.

Specific drug interaction studies have not been conducted with ophthalmic ciprofloxacin.

An overdose is not expected under correct ophthalmic treatment. The unintentional overdosage may be flushed from the eye(s) with warm tap water.

The following steps should be considered to assure the right use of Ciprodol

a. Proper administration technique for applying the solution to the eye.

b. Compliance with full course of therapy.

c. Missed dose: Applying as soon as possible; not applying if almost time for next dose

d. Close bottle immediately after use.

e. Proper storage of the medicament.

Do not use longer than one month after opening. It is advisable to destroy any remaining medicament after completing treatment.

Store in a cool place (below 30 c). Protect from light.