D-Coughsyrup is a cough preparation of expectorant decongestant and antihistamine. It is a combination of guaifenesin, pseudoephedrine and triprodine. Guaifenesin is thought to reduce sputum viscosity by increasing the volume and water content of the bronchial secretion, thus facilitating the expectoration of sputum. Pseudoephedrine is an effective upper respiratory decongestant, which produces its decongestant effect within 30 minutes and its effects lasts for at least 4 hours. Triprodine provides symptomatic relief of allergic rhinitis and common cold.

D-Coughis indicated for the symptomatic relief of productive cough in the following conditions:
♦ Allergic rhinitis
♦ Upper respiratory tract disorders

Adults and children over 12 years: 2 teaspoonful three times a day.
Children:
6-12 years : 1 teaspoonful three times a day.
2-5 years : 1/2 teaspoonful three times a day or as recommended by the physician.

D-Coughis contraindicated in patients with known hypersensitivity to any of its ingredients. It is contraindicated in patients with sever hypertension and severe coronary artery disease. Also contraindicated in person who are taking or have taken monoamine oxidase inhibitors within the preceding two weeks.

Central nervous system depression or excitation may occur, drowsiness being reported most frequently. Sleep disturbance and rarely hallucinations have been reported. Skin rashes with or without irritation, tachycardia, and dryness of mouth, nose and throat have been occasionally reported. Urinary retention may occur in men receiving pseudoephedrine. Prostate enlargement may be an important predisposing factor.

Although pseudoephedrine, guaifenesin and tripolidine have in widespread use for many years without apparent ill consequence, there are no specific data on their use during pregnancy and lactation. So expoten should be used with caution during pregnancy and only if clearly indicated.

D-Coughshould be used with caution in patients taking hypertensive, tricyclic antidepressant or other sympsthomimetic agents. Caution should be taken in severe hepatic and renal impairment. It should not be used for persistent cough due to smoking, asthma or emphysema or where cough is accompanied by excessive secretions unless recommended by a physician.

Do not drive or operate machinery during therapy.

Concomitant use of D-Coughwith other sympathomimetic agents such as decongestants, tricyclic antidepressants, appetite suppressants and amphetamine - like psychostimulant or with monoamine oxidase inhibitors, which interfere with the catabolism of sympathomimetic amines, can occasionally raise the blood pressure. Pseudophedrine in D-Coughmay partially reverse the hypertensive action of drugs, which interfere with sympathetic activity including methyldopa, alpha-and beta-adrenergic blocking agents.

Store in a cool (below 30°c), dry place, away from light. Keep out of reach of children.

D-Cough syrup: Bottle containing 100 ml syrup, Each 5 ml syrup contains guaifensin USP 100 mg, pseudophedrine hydrochloride USP 30 mg and triprolidine hydrochloride USP 1.25 mg.