Aspirin (D-Aspirin) is used mainly as analgesic, antipyretic, antirheumatic and in all types of painful conditions. Moreover its use in cardiovascular disease and in cancer is remarkable.

D-Aspirin75 mg Tablet: Each enteric-coated tablet contains Aspirin BP 75 mg.

Aspirin is an antiplatelet agent. It acts by causing irreversible inhibition of the cyclo-oxygenase enzyme, Which leads to decreased formation of throboxane A2. Since platelets do not synthesize new enzyme, the action of aspirin on platelet cyclo-oxygenase is permanent, lasting for the life of the platelets (7-10 days).

Aspirin is rapidly hydrolyzed primarily in the liver to salicylic acid, which is conjugated with glycine (forming salicyluric acid) and glucuronic acid and excreted largely in the urine. As a result of the rapid hydrolysis, plasma concentrations of aspirin are always low and rarely exceed 20 mcg/ml at ordinary therapeutic doses. The peak salicylate level for uncoated aspirin occurs in about 2 hours; however with enteric coated aspirin tablet this is delayed. The plasma half-life for aspirin is approximately 15 minutes.

Prophylaxis of Myocardial Infarction: Aspirin is indicated to reduce the risk of death and/or nonfatal myocardial infarction in patients with a previous infarction or unstable angina pectoris.
Transient Ischemic Attacks: Aspirin is indicated for reducing the risk of recurrent transient ischemic attacks (TIAs) or stroke in men who have transient ischemia of the brain due to fibrin emboli. There is no evidence that aspirin is effective in reducing transient attack in women, or is of benefit in the treatment of completed strokes in men or women.

Ischemic Stroke and TIA: 50-325 mg once a day. Suspected Acute MI: The initial dose of 160-162.5 mg is administered as soon as an MI is suspected. The maintenance dose of 160-162.5 mg per day is continued for 30 days post-infarction. After 30 days, consider further therapy based on dosage and administration for prevention of recurrent MI. Prevention of Recurrent MI: 75-325 mg once a day.
Unstable Angina Pectoris: 75-325 mg once a day.
Chronic Stable Angina Pectoris: 75-325 mg once a day.

At dosages of 1,000 mg or higher of aspirin per day, gastrointestinal side effects include stomach pain, heartburn, nausea and/or vomiting, as well as increased rates of gross gastrointestinal bleeding.

Hypersensitivity to aspirin and/or NSAIDs, active pathological bleeding such as peptic ulcer or intracranial haemorrhage or bleeding disorders like hemophilia, recent history of gastrointestinal bleeding.

Aspirin should be avoided in last 3 months of pregnancy.

Aspirin should be used with caution when anticoagulants are prescribed concurrently. Patients presenting with signs and/or symptoms of TIAs should have a complete medical and neurologic evaluation. Consideration should be given to other disorders which may resemble TIAs. It is important to evaluate and treat, if appropriate, diseases associated with TIAs and stroke, such as hypertension and diabetes.
Aspirin at dosages of 1,000 mg per day has been associated with small increases in blood pressure, blood urea nitrogen, and serum uric acid levels. It is recommended that patients placed on long-term aspirin treatment should be seen at regular intervals to assess changes in these measurements.

Aspirin may enhance the effect of anticoagulants.

Overdosage of 200 to 500 mg/kg is in the fatal range. Early symptoms are CNS stimulation with vomiting, hyperpnea, hyperactivity, and possibly convulsions. This progresses quickly to depression, coma, respiratory failure, and collapse. These symptoms are accompanied by severe electrolyte disturbances.

Store in a cool and dry place, protected from light.

D-Aspirin 300 mg Tablet: Each carton contains 10x10 tablets in blister pack.