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5th
May 2009
Dolphin has added seven more formulations to its growing
Sri Lanka Portfolio
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28th
April 2009
The Board of Directors of the Company in its 154th
meeting held on Tuesday, 28 April, 2009 has recommended 50% cash and 25% stock
dividend (bonus share)
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| D-Ampicillin Capsule
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| Back |
| DESCRIPTION |
Ampicillin (D-Ampicillin) is a broad spectrum, acid-stable bactericidal antibiotic which covers a wide range of infections caused by both Gram-positive and Gram-negative bacteria.
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| COMPOSITION |
D-Ampicillin 250 mg Capsule : Each Capsule contains Ampicillin BP 250 mg.
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| MODE OF ACTION |
Ampicillin inhibits the transpeptidase enzyme which is responsible for final cell wall synthesis. As a result the bacterial cell wall is weakened and swelled up and is ruptured.
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| INDICATION |
Respiratory tract infections: Tonsillitis, pharyngitis, laryngitis, bronchitis, pneumonia, otitis media, bronchiectasis.
Gastrointestinal tract infections: Typhoid, paratyphoid, bacillary dysentery, gastroenteritis.
Genitourinary tract infections: Cystitis, pyelonephritis, prostatitis, gonococcal urethritis, puerperial sepsis.
Other infections: Post-operative infections, dental infections, septicaemia, endocarditis, meningitis, osteomyelitis.
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| DOSAGE & ADMINISTRATION |
Oral:
Adults: 250-500 mg 6 hourly.
Children: Upto 2 years, 1/4 of the adult dose. 2-10 years, 1/2 of the adult dose; or based on body weight, 25-50 mg/kg/day in divided doses.
For the treatment of bacterial meningitis:
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| SIDE EFFECT |
During therapy with ampicillin, occasional rashes, transient diarrhoea or indigestion may rarely be reported.
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| CONTRAINDICATIONS |
Ampicillin is contraindicated in penicillin hypersensitivity.
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| USE IN PREGNANCY AND LACTATION |
Ampicillin is relatively safe for use in pregnancy. Some amount of drug is found in the breast milk, but this rarely causes any problem, although there is a theoretical risk of sensitizing the baby to penicillin.
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| PRECAUTIONS |
Before administering any member of penicillin, the history of hypersensitivity should be borne in mind. Skin sensitivity test should be done before administration of the drug in parenteral route.
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| DRUG INTERACTION |
Ampicillin interacts with warfarin, oral contraceptives. Plasma concentration of ampicillin is increased by concurrent administration of probenecid. Food may reduce the absorption of ampicillin taken around the time of ampicillin ingestion.
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| OVERDOSAGE |
A little information on acute overdose is available. Toxicity is low and the only adverse effects are nausea, vomiting, and allergic manifestutiry.
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| STORAGE |
Store in a cool and dry place, protected from light.
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| PACKAGING |
D-Ampicillin 250 mg Capsule: Each carton contains 10x10 capsules in blister pack.
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